Leigh are hoping to have Gareth Hock available for their Ladbrokes Challenge Cup tie at Wakefield on Sunday after a hamstring injury.
The former Wigan and Salford forward has missed the last three games but is being tipped to return this weekend.
However, Centurions second rower Martin Aspinwall suffered a knee injury in the reserves game at Dewsbury last Thursday which could keep him out for around eight weeks.
Matt Sarsfield played 20 minutes in the same game as he stepped up his comeback after a pre-season knee operation.
Leigh will also be without prop Jake Emmitt at Wakefield as he serves the second of a two match ban for using abusive language to an official in the recent win over Batley.