Leigh took advantage of defeats by nearest rivals Featherstone and Doncaster to open up a 10-point lead in the Kingstone Press Championship.
The Centurions extended their winning run to 16 matches with a 24-10 victory over Whitehaven at the Recreation Ground.
The Cumbrians scored the game’s first try through winger Craig Calvert and Jessie Joe Parker’s score early in the second half kept them in touch before the prolific Ryan Brierley sealed their fate with his 26th try of the season.
Tommy Goulden, Jonny Pownall and Gregg McNally scored the Centurions’ other tries and Martyn Ridyard kicked four goals.
Workington ended their five-match losing run in dramatic fashion with a 20-18 success at Derwent Park that condemned Featherstone to their first defeat under coach Andy Hay.
Town’s tries were scored by Graeme Mattinson, Andy Morris and Carl Forber, whose four goals proved decisive.
Rovers outscored their hosts in tries, with winger Will Sharp touching down twice and forwards James Lockwood and Andrew Bostock also scoring, but Harry Siejka could land only one conversion.
Featherstone’s bonus point enabled them to extend their strengthen their position in second place after Doncaster went down 24-8 to Dewsbury at the Tetley’s Stadium.
Doncaster were able to give a debut to Hull forward Liam Watts, who was forced to miss his club’s trip to Perpignan after losing his passport, and he scored their only try as they slipped to a first defeat in five matches.
Anthony Thackeray got a try in each half for the Rams, whose other scores came from Kyle Briggs, Callan Beckett and Shane.
The biggest shock of the day came at Owlerton Stadium, where Keighley boosted their survival hopes with a 29-16 win over reigning champions Sheffield Eagles.
Quentin Laulu-Togagae gave the Eagles the lead with a first-minute try, but the visitors showed their intentions by scoring 14 points in a seven-minute spell with tries from James Haley and Josh Lynham and three goals from Danny Jones to open up a handsome lead.
James Craven and Sean Hesketh added further tries in the second half as the Cougars ended their three-match losing run to climb up to eighth in the table.
Dane Straugher and Michael Knowles scored the other tries for Sheffield, who are above the Cougars only on points difference after suffering their seventh defeat of the season.
Batley are up to sixth thanks to a 55-12 win over North Wales Crusaders, the highlight of which was a hat-trick of tries from full-back Miles Greenwood.
Alex Brown touched down twice and the Bulldogs scored other tries through Vinny Finigan, Sam Scott, Luke Blake, Byron Smith and Scott Leatherbarrow, who also kicked seven goals and a drop goal for a personal haul of 19 points.
Dan Birkett and Toby Adamson scored tries for the Crusaders, who were under coach Anthony Murray for the first time.
Wales international Ross Divorty scored four of his side’s eight tries in Halifax’s 42-24 win over struggling Rochdale Hornets at the Shay.
Prop Luke Ambler touched down twice and Ryan Fieldhouse and Luke Adamson got Halifax’s other tries.
Dave Llewellyn, Lewis Sheridan and Chris Baines scored Hornets’ tries.
Barrow sunk to the foot of the table on points difference after going down 38-24 at home to Swinton.
Ed Barber scored a hat-trick of tries for the Lions, with others coming from Mike Morrison, Anthony Bowman, Mick Nanyn and Richie Hawkyard while Gareth O’Brien kicked five goals.
Dan Toal scored two tries for the Raiders, with others coming from Liam Campbell and Max Wiper, with Ryan Shaw kicking four goals.