Leigh will begin their Challenge Cup campaign against Workington Town this year.
The Centurions have impressed in the competition in recent years, running Leeds Rhinos close in 2014 and beating Super League’s Salford and Wakefield Trinity last season before running heavyweights Warrington Wolves close.
A win in the fourth round, which takes place this month, would give them the opportunity to repeat such antics when four Super League clubs join in round five.
An amateur club is guaranteed a place in the fifth round of the Ladbrokes Challenge Cup after two of the five surviving teams were paired together in the fourth-round draw.
Featherstone Lions, the lowest-ranked team left in the competition, were handed a home tie against Castleford neighbours Lock Lane in the draw made by former Cup winners Paul Wellens and Adrian Morley.
Bradford Bulls, who last won the Cup in 2003, were drawn away to Dewsbury in one of five all-Championship ties while the University of Gloucestershire’s reward for knocking out North Wales is a trip to France to take on Toulouse.
The 12 winners of the fourth-round ties will be joined in the draw for the next round by last year’s bottom four Super League clubs, Hull KR, Salford, Widnes and Wakefield, with the other eight top-flight clubs entering at the sixth-round stage.
The fourth-round draw is:
Batley v Whitehaven.
Hunslet v Doncaster.
Sheffield Eagles v Swinton.
Featherstone Lions v Lock Lane.
Oldham v Kells.
Rochdale v Siddal.
Pilkington Recs v Halifax.
Dewsbury v Bradford.
Leigh v Workington.
York v Keighley.
London Broncos v Featherstone Rovers.
Toulouse v University of Gloucestershire.
Ties to be played on the weekend of March 19-20.