The guided busway will be shut for the entire weekend for maintenance work.
No services will run at all on the route on Saturday April 7 and Sunday April 8 so engineers can carry out tasks safely.
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The closure will run the entire length of the concrete guided section from East Bond Street in Leigh to Newearth Road in Salford, with the V1 and V2 buses running instead along local roads.
Alternative bus stops will be used as signposts put up, but the interchange on Astley Street in Tyldesley will remain open.
Services will be back to normal in time for the first bus on Monday April 9.
A map of the closures and diversions is available at www.tfgm.com
Anyone wanting to find out more can also call Transport for Greater Manchester on 0161 244 1000 from 7am-8pm to Monday to Friday and 8am until 8pm at weekends and bank holidays.